Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children.

Julia E M Upton Jennifer A HoangMatilde Leon-PonteYaron FinkelsteinYue Jennifer DuKhosrow AdeliThomas EiweggerEyal GrunebaumPeter Vadas

Published in: Allergy (2022)

Decreased serum PAF-AH activity is a biomarker of severe anaphylaxis. Levels of this enzyme do not change from basal levels during acute anaphylaxis. Our results show that PAF-AH is a biomarker of anaphylaxis severity in children. This key regulatory enzyme may modulate susceptibility to severe anaphylaxis.

Keyphrases

early onset
young adults

drug induced
signaling pathway

transcription factor
respiratory failure

hepatitis b virus
aortic dissection