Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children.
Julia E M UptonJennifer A HoangMatilde Leon-PonteYaron FinkelsteinYue Jennifer DuKhosrow AdeliThomas EiweggerEyal GrunebaumPeter VadasPublished in: Allergy (2022)
Decreased serum PAF-AH activity is a biomarker of severe anaphylaxis. Levels of this enzyme do not change from basal levels during acute anaphylaxis. Our results show that PAF-AH is a biomarker of anaphylaxis severity in children. This key regulatory enzyme may modulate susceptibility to severe anaphylaxis.