Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes.
Anne BriolayAlaeddine El JamalPaul ArnolfoBenoît Le GoffFrédéric BlanchardDavid MagneCarole BougaultPublished in: Arthritis research & therapy (2020)
Our results first settle that BMP factors are locally deregulated in the SpA joint. An unexpected decrease in BMP-4 could be associated to an increase in BMP-2, possibly in response to mechanical and/or cytokine stimulations.