Polymorphisms in the SNRPN gene are associated with obesity susceptibility in a Spanish population.
David AlbuquerqueLicínio MancoLuz M GonzálezGuillermo GervasiniGoitzane Marcaida BenitoJuan R GonzálezRaquel Rodríguez-LópezPublished in: The journal of gene medicine (2018)
To our knowledge, this is the first study reporting an association between variability in the SNRPN gene and the risk of being obese. Interestingly, it was the major allele of each SNP that was found to be associated with the risk of weight gain. Further studies analyzing this locus and the possible additive deleterious capability of SNP combinations could be useful for demonstrating the development of obesity.
Keyphrases
- weight gain
- genome wide
- weight loss
- body mass index
- birth weight
- metabolic syndrome
- copy number
- dna methylation
- type diabetes
- insulin resistance
- adipose tissue
- healthcare
- genome wide identification
- high density
- high fat diet induced
- emergency department
- physical activity
- gene expression
- adverse drug
- genetic diversity
- transcription factor
- case control