Inflammasomes in Mycobacterium tuberculosis-Driven Immunity.
Sebastian WawrockiMagdalena DruszczyńskaPublished in: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2017)
The development of effective innate and subsequent adaptive host immune responses is highly dependent on the production of proinflammatory cytokines that increase the activity of immune cells. The key role in this process is played by inflammasomes, multimeric protein complexes serving as a platform for caspase-1, an enzyme responsible for proteolytic cleavage of IL-1β and IL-18 precursors. Inflammasome activation, which triggers the multifaceted activity of these two proinflammatory cytokines, is a prerequisite for developing an efficient inflammatory response against pathogenic Mycobacterium tuberculosis (M.tb). This review focuses on the role of NLRP3 and AIM2 inflammasomes in M.tb-driven immunity.
Keyphrases
- mycobacterium tuberculosis
- immune response
- inflammatory response
- pulmonary tuberculosis
- toll like receptor
- cell death
- lipopolysaccharide induced
- dendritic cells
- high throughput
- induced apoptosis
- lps induced
- protein protein
- amino acid
- oxidative stress
- nlrp inflammasome
- signaling pathway
- small molecule
- binding protein