A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension.
Tao ZhuangYu LeiJin-Jia ChangYan-Ping ZhouYan LiYan-Xiu LiYong-Feng YangMei-Hua ChenTing MengShi-Man FuLi-Hao HuangWai-San CheangJohn P CookeZhi-Hui DongYing-Nan BaiCheng-Chao RuanPublished in: European heart journal (2023)
The study highlights a novel A2AR-mediated VEGF-independent activation of VEGFR2 signaling in dermal lymphangiogenesis and sodium balance, which might be a potential therapeutic target in salt-sensitive hypertension.