Nicotine enhances intravenous self-administration of cannabinoids in adult rats.
Sierra J StringfieldBryson E SandersJude A SuppoAlan F SvedMary M TorregrossaPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
This study utilizes a dual intravenous self-administration model to investigate the ability of nicotine to enhance cannabinoid intake. Our results demonstrate that the reinforcement enhancing properties of nicotine on drug use extend to include cannabinoids, but that this effect occurs specifically when nicotine is administered alongside the cannabinoid. Interestingly, cannabinoid use did not promote nicotine intake, suggesting this mechanism of reinforcement is specific to nicotine.