Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always.
W R Wayne MartinJohn R YounceMeghan C CampbellBrad A RacetteScott A NorrisMwiza UsheSusan CriswellAlbert A DavisIsabel Alfradique-DunhamBaijayanta MaitiNigel J CairnsRichard J PerrinPaul T KotzbauerJoel S PerlmutterPublished in: Annals of neurology (2022)
Neocortical Lewy bodies almost always accompany dementia in PD; however, they also appear in most PD patients without dementia. In some cases, dementia may occur in patients with PD without neocortical Lewy bodies, ADNC, or small vessel disease. Thus, other factors not directly related to these classic neuropathologic features may contribute to PD dementia. ANN NEUROL 2022.