Exploring the Role of Plasma Lipids and Statins Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.

Mona M Almramhi Christopher FinanCatherine S StormAmand Floriaan SchmidtDemis A KiaRachel Rachel ConeysSandesh ChopadeAroon D HingoraniNick W Wood

Published in: Neurology (2023)

has been reported to mediate some of the pleiotropic effects of statins, we suggest that statins may reduce MS risk via a cholesterol-independent pathway (i.e., RAC2-related mechanism(s)). MR analyses also support a causal effect of HDL-C on MS risk.

Keyphrases

multiple sclerosis
cardiovascular disease
mass spectrometry
ms ms
physical activity
type diabetes
low density lipoprotein