A self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low H 2 O 2 limitations and precisely sterilizing driven by electricity.
Linlin WangQiwen SuYi LiuTajiguli YimamumaimaitiDandan HuJun-Jie ZhuJian-Rong ZhangPublished in: Chemical science (2022)
Accelerating diabetes-related chronic wound healing is a long-sought-after goal in diabetes management. However, therapeutic strategies based on antibiotics or catalysts still face great challenges to break the limitations of antimicrobial resistance, low H 2 O 2 and the blocking effect of bacterial biofilms on antibiotic/catalyst penetration. Herein, we reported a glucose biofuel cell-powered and drug-free antibacterial patch, which consisted of an MAF-7 protected glucose oxidase/horseradish peroxidase anode and a horseradish peroxidase cathode, for treating diabetic wounds. This self-powered patch could take high blood glucose as fuel to generate electricity and abundant reactive oxygen species (ROS) in situ , synergistically regulating local hyperglycemia and breaking the limitations of insufficient ROS caused by low H 2 O 2 levels. In particular, the electric field created by the GBFC could drive the negatively charged bacteria to adhere firmly to the electrode surface. As a result, the ROS produced in situ on the electrodes was localized to the bacteria, realizing precise sterilization. In vivo experiments confirmed that this self-powered patch enabled the wounds on diabetic mice to take a mere 10 days to eliminate inflammation and form mature skin with new hair follicles, demonstrating its great potential in treating bacteria-infected diabetic wounds.
Keyphrases
- wound healing
- blood glucose
- reactive oxygen species
- glycemic control
- antimicrobial resistance
- type diabetes
- reduced graphene oxide
- dna damage
- cell death
- cardiovascular disease
- oxidative stress
- highly efficient
- hydrogen peroxide
- drug induced
- blood pressure
- emergency department
- adverse drug
- insulin resistance
- single cell
- room temperature
- metabolic syndrome
- climate change
- nitric oxide
- skeletal muscle
- carbon nanotubes
- diabetic rats