Effect of a 5-HT2c receptor agonist on urethral closure mechanisms in female rats.
Mifuka OuchiTakeya KittaYukiko KannoMadoka HiguchiMio TogoKimihiko MoriyaNobuo ShinoharaPublished in: Neurourology and urodynamics (2018)
We showed that lorcaserin can activate the external urethral sphincter and pelvic floor muscles, suggesting an influence on active closure mechanisms. 5-HT2c receptors agonists may have dual effects in patients with SUI, not only by reducing obesity but also by enhancing active urethral closure.