Efficacy of Analytical Technologies in Metabolomics Studies of the Gastrointestinal Cancers.
Younes AftabiJafar SoleymaniAbolghasem JouybanPublished in: Critical reviews in analytical chemistry (2021)
According to the reports of the World Health Organization and the International Agency for Research on Cancer, cancer is the second leading cause of human death worldwide. However, early-stage detection of cancers can efficiently enhance the chance of therapy and saving lives. Metabolomics strategies apply a variety of approaches to discover new potential diagnoses, prognoses, and/or therapeutic biomarkers of various diseases. Metabolomics aims to identify and measure different low-molecular-weight biomolecules in physiological environments. In these studies, special metabolites are extracted from biological samples and identified using analytical techniques. Afterward, using data processing programs discovering significantly associated biomarkers is pursued. In the present review, we aimed to discuss recently reported analytical approaches on the metabolomics studies of gastrointestinal cancers including gastric, colorectal, and esophageal cancers. The gas- and liquid-chromatography with different detectors have been shown that are the main analytical techniques and for metabolites quantification, nuclear magnetic resonance has been utilized as a master method.
Keyphrases
- liquid chromatography
- mass spectrometry
- high resolution mass spectrometry
- tandem mass spectrometry
- magnetic resonance
- early stage
- papillary thyroid
- childhood cancer
- case control
- ms ms
- gas chromatography
- squamous cell
- simultaneous determination
- endothelial cells
- solid phase extraction
- high resolution
- public health
- electronic health record
- emergency department
- squamous cell carcinoma
- magnetic resonance imaging
- deep learning
- mesenchymal stem cells
- induced pluripotent stem cells
- young adults
- lymph node
- climate change
- adverse drug
- rectal cancer
- risk assessment
- machine learning
- data analysis
- smoking cessation