Correlation of Lymphocyte Subpopulations, Clinical Features and Inflammatory Markers during Severe COVID-19 Onset.
Angelos LiontosAlexandros-George AsimakopoulosGeorgios S MarkopoulosDimitrios BirosLazaros AthanasiouStavros TsourlosLeukothea DovaIro-Chrisavgi RaptiIlias TsiakasEvangelia E NtzaniEvangelos EvangelouIoanna TzoulakiKonstantinos TsilidisGeorge VartholomatosEvangelia DounousiHaralampos MilionisEirini ChristakiPublished in: Pathogens (Basel, Switzerland) (2023)
Despite a low patient number, this study showed that alterations in lymphocyte subpopulations are associated with COVID-19 severity markers. It was observed that an increase in lymphocytes (CD4 and transiently CD45RARO) resulted in lower CRP levels, perhaps leading to COVID-19 recovery and immune response homeostasis. However, these findings need further evaluation in larger scale trials.