Timing of blood sampling for butyrylcholinesterase phenotyping in patients with prolonged neuromuscular block after mivacurium or suxamethonium.

Nesse MintjensRoy BrummansFiliep SoetensKathleen B M ClaesLuc E Vanlinthout

Published in: Acta anaesthesiologica Scandinavica (2020)

Anaesthesia interfered with BChE activity, but not with phenotyping. Phenotyping can be performed on blood drawn during or immediately after recovery of mivacurium or suxamethonium to screen for clinically relevant variants of BChE. However, accurate diagnosis of BChE deficiency needs further confirmation by determination of genotype.

Keyphrases

high throughput
single cell
copy number
high resolution
gene expression
molecularly imprinted
mass spectrometry
replacement therapy
dna methylation
smoking cessation