Adamantylglycine as a high-affinity peptide label for membrane transport monitoring and regulation.
Malavika PramodMohammad A AlnajjarSandra N SchöpperThomas SchwarzloseWerner M NauAndreas HennigPublished in: Chemical communications (Cambridge, England) (2024)
The non-canonical amino acid adamantylglycine (Ada) is introduced into peptides to allow high-affinity binding to cucurbit[7]uril (CB7). Introduction of Ada into a cell-penetrating peptide (CPP) sequence had minimal influence on the membrane transport, yet enabled up- and down-regulation of the membrane transport activity.