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Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.

Adela Ramirez-TorresAllison L ReaganLauren E HowardEmily K WigginsAdriana C VidalJunxiang WanBrendan MillerStephen J FreedlandPinchas Cohen
Published in: The Prostate (2022)
Higher MDP levels were associated with lower PC risk in EAM but not AAM. Generally, AAM controls had lower MDP levels. These data support MDPs and mitochondrial dysfunction in PC, suggesting greater dysfunction in AAM may contribute to excess PC risk. Future larger studies are needed to confirm these results.
Keyphrases
  • prostate cancer
  • healthcare
  • public health
  • mental health
  • oxidative stress
  • radical prostatectomy
  • cell death
  • reactive oxygen species
  • risk assessment
  • big data
  • machine learning
  • deep learning
  • endoplasmic reticulum