Risk of lower extremity amputations in people with type 2 diabetes mellitus treated with sodium-glucose co-transporter-2 inhibitors in the USA: A retrospective cohort study.

Zhong YuanFrank J DeFalcoPatrick B RyanMartijn J SchuemiePaul E StangJesse A BerlinMehul DesaiNorm Rosenthal

Published in: Diabetes, obesity & metabolism (2017)

This real-world study observed no evidence of increased risk of BKLE amputation for new users of canagliflozin compared with non-SGLT2 inhibitor AHAs in a broad population of patients with T2DM.

Keyphrases

lower limb
type diabetes
metabolic syndrome
skeletal muscle
insulin resistance