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Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India.

María Camila Alvarez-SilvaAlireza KashaniTue Haldor HansenNishal Kumar PinnaRanjit Mohan AnjanaAnirban DuttaShruti SaxenaJulie StøyUlla KampmannTrine NielsenTorben JørgensenVisvanathan GnanaprakashRameshkumar GnanavadivelAswath SukumaranCoimbatore Subramanian Shanthi RaniKristine FærchVenkatesan RadhaMuthuswamy BalasubramanyamGopinath Balakrish NairBhabatosh DasHenrik VestergaardTorben HansenSharmila Shekhar MandeViswanathan MohanManimozhiyan ArumugamOluf Pedersen
Published in: Genome medicine (2021)
We demonstrate major compositional differences of the gut microbiota between Danish and South Indian individuals, some of which may relate to differences in ethnicity, lifestyle, and demography. By comparing metformin-naive T2D patients and normoglycemic individuals, we identify T2D-related microbiota changes in the Danish and Indian study samples. In the present trans-ethnic study, we confirm that metformin changes the taxonomic profile and functional potential of the gut microbiota.
Keyphrases
  • type diabetes
  • cardiovascular disease
  • newly diagnosed
  • ejection fraction
  • metabolic syndrome
  • gene expression
  • weight loss
  • skeletal muscle
  • hiv infected
  • drug induced
  • patient reported outcomes