Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore.
Joseph WillisRobert A AndersToshihiko TorigoeYoshihiko HirohashiCarlo BifulcoInti ZlobecBernhard MlecnikSandra DemariaWon-Tak ChoiPavel DundrFabiana TatangeloAnnabella Di MauroPamela BaldinGabriela BindeaFlorence MarliotNacilla HaicheurTessa FredriksenAmos KirilovskyBénédicte ButtardAngela VasaturoLucie LafontainePauline MabyCarine El SissyAssia HijaziAmine MajdiChristine LagorceAnne BergerMarc Van den EyndeFranck PagèsAlessandro LugliJérôme GalonPublished in: Cancers (2023)
The standardized IS assay outperformed expert pathologists' T-score evaluation in the clinical setting. This study demonstrates that digital pathology, in particular digital IS, represents a novel generation of immune pathology tools for reproducible and quantitative assessment of tumor-infiltrated immune cell subtypes.
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