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Promoter evolution of mammalian gene duplicates.

Evgeny FraimovitchTzachi Hagai
Published in: BMC biology (2023)
In this work, we profiled promoters of gene duplicates and their inter-paralog divergence. We also studied how their characteristics are associated with duplication time and duplication mechanism, as well as with the fate of these duplicates. These results underline the importance of cis-regulatory mechanisms in shaping the evolution of new genes and their fate following duplication.
Keyphrases
  • genome wide identification
  • genome wide
  • transcription factor
  • dna methylation
  • copy number
  • genome wide analysis
  • gene expression