CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.

Gerben BoumaStefano ZamunerKirsty HicksAndrew WantJoão OliveiraArpita ChoudhurySara BrettDarren RobertsonLeigh FeltonVirginia NorrisDisala FernandoMichael HerdmanRuth Tarzi

Published in: British journal of clinical pharmacology (2017)

These results indicate a relationship between PK, target engagement and PD, suggesting a selective inhibition of recruitment of CCR6+ cells by GSK3050002 and support further development of GSK3050002 in autoimmune and inflammatory diseases.

Keyphrases

induced apoptosis
monoclonal antibody
cell cycle arrest
signaling pathway
pi k akt
dendritic cells
oxidative stress
multiple sclerosis
endoplasmic reticulum stress
cell death
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