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Conducting Composite Material Based on Chitosan and Single-Wall Carbon Nanotubes for Cellular Technologies.

Vera Vladimirovna Kodolova-ChukhontsevaMikhail Alexandrovich ShishovKonstantin Andreevich KolbeNatalia Vladimirovna SmirnovaIrina Petrovna Dobrovol'skayaElena Nikolaevna DresvyaninaSergei Gennadievich BystrovNadezda Semenovna TerebovaAlmaz Maratovich KamalovAnna Ericovna BursianElena Mikhailovna Ivan'kovaVladimir Evgenievich Yudin
Published in: Polymers (2022)
Biocompatible electrically conducting chitosan-based films filled with single-wall carbon nanotubes were obtained. Atomic force microscopic studies of the free surface topography revealed a change in the morphology of chitosan films filled with single-wall carbon nanotubes. Introducing 0.5 wt.% of single-wall carbon nanotubes into chitosan results in an increase in tensile strength of the films (up to ~180 MPa); the tensile strain values also rise up to ~60%. It was demonstrated that chitosan films containing 0.1-3.0 wt.% of single-wall carbon nanotubes have higher conductivity (10 S/m) than pure chitosan films (10 -11 S/m). The investigation of electrical stimulation of human dermal fibroblasts on chitosan/single-wall carbon nanotubes film scaffolds showed that the biological effect of cell electrical stimulation depends on the content of single-walled carbon nanotubes in the chitosan matrix.
Keyphrases
  • carbon nanotubes
  • drug delivery
  • wound healing
  • hyaluronic acid
  • stem cells
  • endothelial cells
  • single cell
  • walled carbon nanotubes