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T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting.

Christopher J HanleyGareth J Thomas
Published in: British journal of cancer (2020)
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
Keyphrases
  • cancer therapy
  • drug delivery
  • extracellular matrix
  • reactive oxygen species
  • case control