CuCo2S4 nanocrystals: a new platform for multimodal imaging guided photothermal therapy.
Xiaojuan HuangGuoying DengLijun LiaoWenlong ZhangGuoqiang GuanFeng ZhouZhiyin XiaoRujia ZouQian WangJunqing HuPublished in: Nanoscale (2018)
Multifunctional nanomaterials open an avenue for the integration of cancer treatment and diagnosis, trending towards the clinical application of nanomedicines in future. Herein, we synthesized biocompatible CuCo2S4 nanocrystals (NCs) via a simple reflux method and unitized them as a new theranostic platform, where an intense near-infrared (NIR) absorption offers the CuCo2S4 NCs a perfect photothermal performance and photoacoustic (PA) imaging ability; the magnetic characteristic of Co allows them to serve as an enhanced magnetic resonance (MR) contrast agent. The in vitro and in vivo experiments demonstrated their good biocompatibility, non-toxicity and perfect photothermal conversion performance and further confirmed that HeLa tumors could be effectively thermal-ablated upon the assistance of the CuCo2S4 NCs. This work introduces the first bioapplication of the CuCo2S4 NCs and promotes theranostics based on other ternary compounds.
Keyphrases
- magnetic resonance
- photodynamic therapy
- fluorescence imaging
- drug release
- cancer therapy
- drug delivery
- high resolution
- contrast enhanced
- high throughput
- room temperature
- minimally invasive
- oxidative stress
- pain management
- energy transfer
- current status
- mass spectrometry
- fluorescent probe
- cell death
- cell proliferation
- tandem mass spectrometry