Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Preethi H GunaratneYinghong PanAbhi K RaoChunru LinAnadulce Hernandez-HerreraKe LiangAntonina S RaitAvinashnarayan VenkatanarayanAshley L BenhamFarwah RubabSang Soo KimKimal RajapaksheClara K ChanLingegowda S MangalaGabriel Lopez-BeresteinAnil K SoodAmy C RowatCristian CoarfaKathleen F PirolloElsa R FloresEsther H Chang

Published in: Cancer (2019)

The miR-130b/TAp63 axis is proposed as a new druggable pathway that has the potential to uncover broad-spectrum therapeutic options for the majority of p53-altered cancers.

Keyphrases

signaling pathway
cancer therapy
human health
risk assessment
climate change