Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma.
Amandine VargasRoxane BoivinPatricia CanoYoana MurciaIsabelle BazinJean-Pierre LavoiePublished in: Respiratory research (2017)
GC decreased NETs formation in vitro and also in vivo in the lungs of asthmatic horses. However, airway neutrophil activation during asthmatic inflammation was otherwise relatively insensitive to GC. The contribution of IL-17 to these responses requires further study.