Comparative effectiveness of mesenchymal stem cell versus bone-marrow mononuclear cell transplantation in heart failure: a meta-analysis of randomized controlled trials.
Alireza HosseinpourJahangir KamalpourNiloofar Dehdari EbrahimiSeyed Alireza MirhosseiniAlireza SadeghiShahin KavousiArmin AttarPublished in: Stem cell research & therapy (2024)
Both types of stem cells are effective in improving LVEF in patients with heart failure without any noticeable difference between the cells. Transplantation of the stem cells could not decrease the risk of major adverse cardiovascular events compared with controls. Future trials should primarily focus on the impact of stem cell transplantation on clinical outcomes of HF patients to verify or refute the findings of this study.
Keyphrases
- stem cells
- stem cell transplantation
- cell therapy
- cardiovascular events
- bone marrow
- mesenchymal stem cells
- heart failure
- end stage renal disease
- high dose
- coronary artery disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- cardiovascular disease
- chronic kidney disease
- systematic review
- single cell
- prognostic factors
- acute heart failure
- left ventricular
- type diabetes
- emergency department
- umbilical cord
- low dose
- peritoneal dialysis
- cell cycle arrest
- peripheral blood
- cell proliferation
- patient reported outcomes
- endoplasmic reticulum stress
- cardiac resynchronization therapy
- patient reported