Variable Genomic Landscapes of Advanced Melanomas with Heavy Pigmentation.
Richard S P HuangJulie Y TseLukas HarriesRyon P GrafDouglas I LinKarthikeyan MurugesanMatthew C HiemenzVamsi ParimiTyler JanovitzBrennan DeckerEric SeversonMia A LevyShakti H RamkissoonJulia A ElvinJeffrey S RossErik A WilliamsPublished in: The oncologist (2022)
In this study, we quantified the failure rates of melanoma samples for PD-L1 testing due to high melanin pigmentation and showed that CGP can be used in these patients to identify biomarkers that can guide treatment decisions for HPMel patients. Using this practical clinical definition for tumor pigmentation, our results indicate that HPMel are frequent at 13% of melanoma samples, and in general appear molecularly less developed, with a lower TMB and less frequent secondary GA of melanoma progression.