Sarcosenones A-C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

Xintong HouYang XuShuaiming ZhuYang ZhangLiangdong GuoFeng QiuYongsheng Che

Published in: RSC advances (2020)

Three new highly oxygenated pimarane diterpenoids, sarcosenones A-C (1-3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compound 1 showed moderate cytotoxicity against a small panel of four human tumor cell lines, with IC 50 values of 7.5-26.4 μM.

Keyphrases

high resolution
endothelial cells
molecular docking
magnetic resonance
density functional theory
electronic health record
molecular dynamics simulations
high intensity
induced pluripotent stem cells
big data
monte carlo