Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China.
Hm Adnan HameedYaoju TanMd Mahmudul IslamZhili LuChiranjibi ChhotarayShuai WangZhiyong LiuCuiting FangShouyong TanWing Wai YewNanshan ZhongJianxiong LiuTian-Yu ZhangPublished in: Infection and drug resistance (2020)
Our study revealed that PZAR rate in MDR and pre-XDR TB was markedly higher in southern China. The concomitant evaluation of pncA + UFR, rpsA, panD, Rv2783c, and Rv2044c provides more dependable genotypic results of PZA resistance. Fifty-seven novel mutations/indels in this study may play a vital role as diagnostic markers. The upstream region of pncA and PZase regulation are valuable to explore the unknown mechanism of PZA-resistance.