Opioid therapy duration before naldemedine treatment is a significant independent risk of diarrhea: a retrospective cohort study.
Akiharu OkamotoKenji IkemuraEri MizutaniTakuya IwamotoMasahiro OkudaPublished in: Journal of pharmaceutical health care and sciences (2021)
These results suggested that a prolonged duration of opioid therapy prior to NAL initiation is associated with increased incidence of diarrhea.