Quantitative image analysis for CD8 score in lung small biopsies and cytology cell-blocks.

Sara E MonacoSanja DacicLindsey SeighDouglas J HartmanJuan XingLiron Pantanowitz

Published in: Cytopathology : official journal of the British Society for Clinical Cytology (2020)

These findings show that CD8 density in NSCLC can be quantified by IA in small biopsies and cell blocks, achieving the best concordance using WSI scores. Discrepancies were attributed to values near the cut-off and background detection of staining. These data warrant future studies with more cases and follow-up data to further investigate the clinical utility of IA for CD8 analysis in NSCLC.

Keyphrases

small cell lung cancer
single cell
cell therapy
electronic health record
advanced non small cell lung cancer
ultrasound guided
high resolution
stem cells
high grade
current status
data analysis
mesenchymal stem cells
loop mediated isothermal amplification
artificial intelligence
case control