Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease.
Jun WangQiao YeWen Jie ZhengXiaomin YuFang LuoRan FangYaoyao ShangguanZhijun DuPui Y LeeTaijie JinQing ZhouPublished in: Annals of the rheumatic diseases (2022)
mutation in a small subset of leucocytes. We systemically analysed this condition at a single-cell transcriptomic level and revealed specific enhancement of inflammatory response in myeloid cells.
Keyphrases
- late onset
- single cell
- inflammatory response
- rna seq
- early onset
- induced apoptosis
- high throughput
- cell cycle arrest
- lipopolysaccharide induced
- dendritic cells
- bone marrow
- acute myeloid leukemia
- endoplasmic reticulum stress
- lps induced
- gene expression
- oxidative stress
- toll like receptor
- signaling pathway
- cell death
- cell proliferation
- pi k akt