Pharmacokinetic Assessment of Pre- and Post-Oxygenator Vancomycin Concentrations in Extracorporeal Membrane Oxygenation: A Prospective Observational Study.
Ahmed A MahmoudSean N AvedissianAbbas Al-QamariTiffany BohlingMichelle PhamMarc H ScheetzPublished in: Clinical pharmacokinetics (2021)
Extracorporeal membrane oxygenation flow rates did not influence vancomycin clearance between flow rates of 3500 and 5000 mL/min and vancomycin was not sequestered in ECMO. Common vancomycin regimens resulted in suboptimal efficacy and/or excessive toxicity. Individual therapeutic drug monitoring is recommended for patients on ECMO.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- methicillin resistant staphylococcus aureus
- respiratory failure
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- mechanical ventilation
- prognostic factors
- staphylococcus aureus
- oxidative stress
- physical activity