Sequential ortho -/ meta -C-H functionalizations of N -tosyl-benzamides for the synthesis of polyfunctionalized arenes.

Selective one-pot sequential ortho -/ meta -C-H functionalizations provided highly desirable polyfunctionalized arenes. Starting from readily available carboxylic acid derivatives, the concomitant formation of C-O and C-halogen bonds was achieved under mild reaction conditions (12 examples, up to 75% yield). The utility of the products was illustrated with post-functionalization reactions and Metiglinid synthesis.