Gut-brain axis dysfunction underlies FODMAP-induced symptom generation in irritable bowel syndrome.
Jie WuImke MasuyJessica R BiesiekierskiHeather E FitzkeChinar ParikhLaurel SchofieldHafsa ShaikhAnisha BhagwananiQasim AzizStuart A TaylorJan TackLukas Van OudenhovePublished in: Alimentary pharmacology & therapeutics (2022)
Fructans increase small bowel motility and colon gas and volume similarly in IBS patients and HC. Increased symptom responses to fructans in IBS covary with altered brain responses in pain-related regions, indicating that gut-brain axis dysregulation may drive FODMAP-induced symptom generation in IBS.
Keyphrases
- irritable bowel syndrome
- resting state
- white matter
- small bowel
- high glucose
- patient reported
- end stage renal disease
- diabetic rats
- ejection fraction
- functional connectivity
- chronic kidney disease
- newly diagnosed
- cerebral ischemia
- peritoneal dialysis
- prognostic factors
- endothelial cells
- escherichia coli
- multiple sclerosis
- room temperature
- cystic fibrosis