IL-33/ST2 axis of human amnion fibroblasts participates in inflammatory reactions at parturition.

Wen-Jia LeiFan ZhangYi-Kai LinMeng-Die LiFan PanKang SunWang-Sheng Wang

Published in: Molecular medicine (Cambridge, Mass.) (2023)

IL-33/ST2 axis is present in human amnion fibroblasts, which is activated in both term and preterm labor. Activation of this axis leads to increased production of inflammatory factors pertinent to parturition, and results in preterm birth. Targeting the IL-33/ST2 axis may have potential value in the treatment of preterm birth.

Keyphrases

preterm birth
gestational age
low birth weight
endothelial cells
oxidative stress
preterm infants
induced pluripotent stem cells
extracellular matrix
cancer therapy
risk assessment
drug delivery