Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa.

Lucas E Hermans Petro Booysen Linda Boloko Marguerite Adriaanse Timothy J de Wet Aimee R Lifson Naweed Wadee Nectarios S Papavarnavas Gert J K Marais Nei-Yuan Hsiao Michael-Jon Rosslee Gregory Symons Gregory L Calligaro Arash Iranzadeh Robert John Wilkinson Ntobeko A B Ntusi Carolyn Williamson Mary-Ann Davies Graeme Meintjes Sean Wasserman

Published in: Southern African journal of infectious diseases (2023)

This study summarises clinical characteristics associated with SARS-CoV-2 variants during the COVID-19 pandemic at a South African tertiary hospital, demonstrating a waning impact of COVID-19 on healthcare services over time despite epidemic waves driven by new variants. Findings suggest the absence of increasing virulence from later variants and protection from population and individual-level immunity.

Keyphrases

sars cov
south africa
healthcare
copy number
coronavirus disease
respiratory syndrome coronavirus
hiv positive
escherichia coli
pseudomonas aeruginosa
primary care
mental health
gene expression
biofilm formation
cystic fibrosis