Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.

Surya P AmarachinthaReena MouryaHiroaki AyabeLi YangZhenhua LuoXiaofeng LiUnmesha ThanekarPranavkumar ShivakumarJorge A Bezerra

Published in: Hepatology (Baltimore, Md.) (2021)

Organoids from biliary atresia are viable and have evidence of halted epithelial development. The induction of developmental markers, improved cell-cell junction, and decreased epithelial permeability by EGF and FGF2 identifies potential strategies to promote epithelial maturation and function.

Keyphrases

single cell
cell therapy
stem cells
endothelial cells
genome wide
gene expression
dna methylation