Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes.
Tong YangKai SunChun WangGaurav SwarnkarSongtao QuanDustin KressJianqiu XiaoYael AlippeHongjun ZhengRobert H BrophyDingjun HaoAudrey McAlindenYousef Abu-AmerJie ShenGabriel MbalavielePublished in: Arthritis research & therapy (2021)
GSDMD plays a key role in the pathogenesis of PTOA, but not STIA, suggesting that its actions in experimental arthropathy are tissue context-specific.