STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells.

Han ZhangLi ChenJiachen LiJiashu SunQixu ZhaoSheng WangGang Li

Published in: Genes & genomics (2024)

These data indicated that STAT3 phosphorylation at Tyr705 impacted DRP1-controlled mitochondrial fission during the development of apoptosis-resistance in PAECs, suggesting mitochondrial dynamics may represent a therapeutic target for PAH.

Keyphrases

oxidative stress
endothelial cells
cell death
cell proliferation
pulmonary hypertension
protein kinase
endoplasmic reticulum stress
electronic health record
big data
deep learning
high glucose
artificial intelligence