Adaptive Metabolic and Inflammatory Responses Identified Using Accelerated Aging Metrics Are Linked to Adverse Outcomes in Severe SARS-CoV-2 Infection.

Alejandro Márquez-SalinasCarlos A Fermín-MartínezNeftalí Eduardo Antonio-VillaArsenio Vargas-VázquezEnrique C GuerraAlejandro Campos-MuñozLilian Zavala-RomeroRoopa MehtaJessica Paola Bahena-LópezEdgar Ortiz-BrizuelaMaría Fernanda González-LaraCarla M Roman-MontesBernardo A Martinez-GuerraAlfredo Ponce de LeonJosé Sifuentes-OsornioLuis Miguel Gutiérrez-RobledoCarlos A Aguilar-SalinasOmar Yaxmehen Bello-Chavolla

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)

Adaptive responses related to accelerated aging metrics are linked to adverse COVID-19 outcomes and have unique and distinguishable features. PhenoAge is a better predictor of adverse outcomes compared to CA.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
early onset
metabolic syndrome
protein kinase
skeletal muscle