The -44 C/G (rs1800972) polymorphism of the β-defensin 1 is associated with increased risk of developing type 2 diabetes mellitus.

Marco Antonio Martinez-RiosGilberto Vargas-AlarconMarco Antonio Peña-DuqueOscar Perez-MendezJose Manuel Rodriguez-PerezNonanzit Perez-HernandezGabriel Herrera-MayaRosalinda Posadas-SanchezCarlos Posadas-RomeroJosé Manuel Fragoso

Published in: Molecular genetics & genomic medicine (2018)

This study demonstrates that the C allele of -44 C/G polymorphism, as well as haplotype AC are associated with the presence of T2DM in the Mexican population. The variation in this polymorphism of the DEFB1 gene could increase the migration of the macrophages to pancreatic islets accelerate the β-cell dysfunction in T2DM.

Keyphrases

glycemic control
single cell
oxidative stress
genome wide
cell therapy
type diabetes
copy number
stem cells
gene expression
bone marrow
cardiovascular risk factors