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Development of polypeptide-based materials toward messenger RNA delivery.

Bowen ZhaoXiao ZhangMolly S BickleShiwei FuQingchun LiFuwu Zhang
Published in: Nanoscale (2024)
Messenger RNA (mRNA)-based therapeutic agents have demonstrated significant potential in recent times, particularly in the context of the COVID-19 pandemic outbreak. As a promising prophylactic and therapeutic strategy, polypeptide-based mRNA delivery systems attract significant interest because of their low cost, simple preparation, tuneable sizes and morphology, convenient large-scale production, biocompatibility, and biodegradability. In this review, we begin with a brief discussion of the synthesis of polypeptides, followed by a review of commonly used polypeptides in mRNA delivery, including classical polypeptides and cell-penetrating peptides. Then, the challenges against mRNA delivery, including extracellular, intracellular, and clinical barriers, are discussed in detail. Finally, we highlight a range of strategies for polypeptide-based mRNA delivery, offering valuable insights into the advancement of polypeptide-based mRNA carrier development.
Keyphrases
  • binding protein
  • low cost
  • stem cells
  • mass spectrometry
  • climate change
  • bone marrow
  • risk assessment
  • high resolution
  • nucleic acid
  • tandem mass spectrometry