Grade and stage misclassification in intermediate unfavorable-risk prostate cancer radiotherapy candidates.
Gabriele SorceRocco Simone FlammiaBenedikt HoehFrancesco ChierigoLukas HohenhorstAndrea PanunzioArmando StabileGiorgio GandagliaZhe TianDerya TilkiCarlo TerroneMichele GallucciFelix K H ChunAlessandro AntonelliFred SaadShahrokh F ShariatFrancesco MontorsiAlberto BrigantiPierre I KarakiewiczPublished in: The Prostate (2022)
IU PCa patients showed very high (36%) upgrading and/or upstaging proportion. Interestingly, the overwhelming majority of those were upstaged to NOC. Conversely, very few were upgraded to GGG ≥ 4. In consequence, more than one-third of IU PCa patients treated with RT may be exposed to suboptimal dose and/or type of RT and to insufficient duration of ADT, since their true grade and stage corresponded to high-risk PCa definition, instead of IU PCa. Data about magnetic resonance imaging were not available but may potentially help with better stage discrimination.
Keyphrases
- prostate cancer
- magnetic resonance imaging
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- early stage
- radical prostatectomy
- computed tomography
- prognostic factors
- squamous cell carcinoma
- electronic health record
- magnetic resonance
- big data
- patient reported
- artificial intelligence
- patient reported outcomes
- rectal cancer