The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala.

Ayako KawaminamiDaisuke YamadaToshinori YoshiokaAzumi HatakeyamaMoeno NishidaKeita KajinoTsuyoshi SaitohHiroshi NagaseAkiyoshi Saitoh

Published in: Neuropsychopharmacology reports (2023)

Our findings indicate that the PL-BLA circuit contributes to innate anxiety and that the anxiolytic-like effects of KNT-127 are mediated at least in part by suppression of PL-BLA transmission. The PL delta-opioid receptor may thus be an effective therapeutic target for anxiety disorders.

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