Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol.
Shih-Cheng ChenMing-Hui YangTze-Wen ChungTing-Syuan JhuangJean-Dean YangKo-Chin ChenWan-Jou ChenYing-Fong HuangShiang-Bin JongWan-Chi TsaiPo-Chiao LinYu-Chang TyanPublished in: BioMed research international (2017)
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Keyphrases
- drug delivery
- drug release
- cancer therapy
- hyaluronic acid
- single cell
- cell therapy
- induced apoptosis
- magnetic resonance
- cell proliferation
- magnetic resonance imaging
- cell cycle arrest
- high resolution
- positron emission tomography
- endoplasmic reticulum stress
- optical coherence tomography
- optic nerve
- adverse drug
- tandem mass spectrometry
- ionic liquid