Arrhythmias including atrial fibrillation and congenital heart disease in Kleefstra syndrome: a possible epigenetic link.
Sunil K VasireddiTanja Zdolsek DrakslerArianne BoumanJoost KummelingMatthew T WheelerNicolette ChunSiddharth SrivastavaJacqueline HarrisPaul Graham FisherSanjiv M NarayanPaul J WangNitish BadhwarTjitske KleefstraMarco Valentin PerezPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)
In addition to a high prevalence of CHD, evolving data reveal early-onset atrial tachyarrhythmias in young KS patients, including AF, even in the absence of structural heart disease.
Keyphrases
- congenital heart disease
- early onset
- atrial fibrillation
- end stage renal disease
- late onset
- chronic kidney disease
- catheter ablation
- newly diagnosed
- ejection fraction
- left atrial
- gene expression
- oral anticoagulants
- direct oral anticoagulants
- heart failure
- electronic health record
- left atrial appendage
- patient reported outcomes
- percutaneous coronary intervention
- venous thromboembolism
- machine learning
- single cell
- coronary artery disease
- genome wide
- artificial intelligence
- deep learning
- left ventricular