Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures.

Cassandra VerheulIoannis NtafoulisTrisha V KersYouri HoogstratePier G MastroberardinoSander BarnhoornCésar Payán-GómezRomain Tching Chi YenEduard A StruysStijn L W KoolenClemens M F DirvenSieger LeenstraPim J FrenchMartine L M Lamfers

Published in: Neuro-oncology advances (2021)

Our twelve IDH-mutant cell cultures show high similarity to the parental tissues and offer a unique tool to study the biology and drug sensitivities of high-grade IDHmt gliomas in vitro. Our drug screening studies reveal lack of sensitivity to IDHmt inhibitors, but sensitivity to a set of nine available anti-cancer agents.

Keyphrases

high grade
low grade
single cell
wild type
cell therapy
adverse drug
gene expression
electronic health record