Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2?
Simone Andrea Rørdam PreilAnne-Sofie Faarvang ThorsenAnne Lindegaard ChristiansenMikael Kjær PoulsenMorten Asser KarsdalDiana Julie LeemingLars Melholt RasmussenPublished in: Scandinavian journal of clinical and laboratory investigation (2017)
Our results suggest that the diabetic environment affects the circulating amounts of MMP-2 and ELM in patients with PAD. However, the same connection could not be seen in diabetic patients with CVD broadly identified in three vascular territories. LOX and ELM-2 did not correlate to any type of CVD. Overall, serum levels of elastin-related molecules are only remotely related to CVD in type 2 diabetes.