Exosomes derived from astrocytes after oxygen-glucose deprivation promote differentiation and migration of oligodendrocyte precursor cells in vitro.

Yaping XuYeye TianYao WangLi XuGuini SongQiao WuWei WangMin-Jie Xie

Published in: Molecular biology reports (2021)

AS-Exo improve OPCs' differentiation and migration, whereas AS-Exo with severe hypoxic precondition suppress OPCs' proliferation. AS-Exo may be a potential therapeutic target for myelin regeneration and repair in white matter injury or other demyelination related diseases.

Keyphrases

white matter
stem cells
induced apoptosis
multiple sclerosis
signaling pathway
cell cycle arrest
mesenchymal stem cells
early onset
endoplasmic reticulum stress
blood glucose
drug induced
cell death
metabolic syndrome
human health
adipose tissue
climate change